The Virulence and Immunogenicity of Strains Derived from Salmonella Typhosa 58 (panama Carrier)
نویسندگان
چکیده
An investigation of the immunogenicity of vaccines prepared from closely related virulent and avirulent strains of S. typhosa is reported. No evidence was obtained of any essential relationship between the virulence of the strains employed and their immunogenicity, as determined by active-immunity mouse-protection tests and by the agglutinin and mouse-protective antibody response in human beings.
منابع مشابه
Y of Strains Derived from Salmonella Typhosa 58 ( Panama Carrier
Since the early days of immunology, it has been considered that high viru-lence and recency of isolation from pathological material were essential attributes of strains of bacteria to be used in production of superior immunizing agents. In spite of a surprising paucity of supporting factual information this concept has pesisted. Perhaps in no field of investigative immunology has the theory of ...
متن کامل232 Virulence and Imm
Since the early days of immunology, it has been considered that high viru-lence and recency of isolation from pathological material were essential attributes of strains of bacteria to be used in production of superior immunizing agents. In spite of a surprising paucity of supporting factual information this concept has pesisted. Perhaps in no field of investigative immunology has the theory of ...
متن کاملDetermination of Differences in Virulence of Strains of Salmonella Typhosa
An investigation is reported of a comparison by three methods of the degree and certainty of differentiation of strains of S. typhosa of different virulence for mice. These methods were (a) intracerebral injection, (b) intraperitoneal injection of saline suspensions, and (c) intraperitoneal injection of mucin suspensions of the test organisms. With the strains of S. typhosa employed, differenti...
متن کاملDiploid Heterozygous Hybrids from Matings between Escherichia Coli and Salmonella Typhosa
An Hfr strain of E. coli K-12 has been shown to mate at low frequency with a number of strains of S. typhosa. The hybrids, selected as lactose positives, retained all other antigenic and biochemical manifestations of the S. typhosa parent. A Lac(+) hybrid, S. typhosa strain 643L(+) was remated with the E. coli Hfr and plated on minimal media containing L-arabinose, D-xylose, L-rhamnose, or L-fu...
متن کاملRole of typhoid antigens in protection and pathogenicity for mice.
Swiss white mice immunized with acetone-killed vaccines prepared from strains of Salmonella typhosa, S. typhimurium, and mouse-virulent S. typhimurium hybrids which had acquired, by conjugal genetic transfer, the S. typhosa antigens 9, Vi, and d were challenged with the S. typhimurium hybrids and with the S. typhimurium parent strain. The results of these experiments suggested that the Salmonel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 91 شماره
صفحات -
تاریخ انتشار 1950